+ Angiogenesis - 'Evidence that tumors are angiogenesis dependent.'
+ Biopsy - 'Accuracy of digital infrared imaging for breast cancer detection in women undergoing breast biopsy.'
+ Chemotherapy - 'Contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies.'
+ DCIS - 'Rethinking the Standard for DCIS Treatment.'
+ 'Management of Axillary Lymph Node Metastasis in Breast Cancer.'
+ Mammography - 'Twenty five year follow-up for breast cancer incidence and mortality.'
+ Mammography - 'Effect of 3 Decades of Mammography on Breast-Cancer Incidence.'
+ Imaging - 'Benefits and harms of screening for cancer with a focus on breast screening.'
+ Imaging - 'Breast cancer: new technologies for risk assessment and diagnosis.'
+ Imaging - 'Comparative study of analytical software identifying different stages of breast cancer using temperature data.'
+ Imaging - 'Progress in screening methods for early breast cancer.'
+ Thermography - 'Advanced integrated technique in breast cancer thermography.'
+ Thermography - 'Association of infrared imaging findings of the breast with hormone receptor and human epidermal growth factor receptor 2 status of breast cancer.'
+ Thermography - 'Breast thermography is a noninvasive prognostic procedure that predicts tumour growth rate.'
+ Thermography - 'Consistency of thermographic findings in the breast'
+ Thermography - 'Detecting early breast tumour by finite element thermal analysis.'
+ Thermography - 'Dynamic infrared imaging-based diagnostic process for breast cancer.'
+ Thermography - 'Effectiveness of a digital infrared thermal imaging system in the detection of breast cancer.'
+ Thermography - 'Feasible method for screening breast cancer?'
+ Thermography - 'Impact of human epidermal growth factor receptor-2 status of invasive breast tumors on thermography findings.'
To analyze the impact of prognostic human epidermal growth factor receptor-2 (HER-2) in invasive breast cancers on the findings of thermography tests.
The study was carried out at the Department of Surgical Oncology and the Department of Pathology, University Clinical Hospital Center, Sisters of Mercy, Zagreb, Croatia, in collaboration with licensed infrared (IR) thermography experts. The study involved 75 female patients diagnosed with invasive breast cancer from May to July 2011. Thermography findings were compared between different immune-histochemical (IHC) findings (HER-2 status: positive or negative).
Significantly higher temperatures were recorded in invasive cancer breasts than in healthy breasts. The cancer sites and the entire cancer breasts were significantly warmer (p less than 0.001) than the healthy breasts and opposite tumors mirror sites. Considering the HER-2 status, HER-2 positive invasive cancers were significantly warmer in comparison with the HER-2 negative cancers (p=0.035).
The trend of increased temperature in HER-2+ tumors was noted. The findings clearly indicate that HER-2+ status has a higher impact on the increased thermographic temperature findings. Source: http://www.ncbi.nlm.nih.gov/pubmed/?term=23047218
+ Thermography - 'Importance of the thermographic study method in oncology'
+ Thermography - 'Improvement in the early detection of breast cancer by thermography.'
+ Thermography - 'Influence of hormonal status on thermography findings.'
+ Thermography - 'Novel functional infrared imaging system coupled with multi-parametric computerised analysis for risk assessment of breast cancer.'
We evaluated a functional three-dimensional (3D) infrared imaging system (3DIRI) coupled with multiparametric computer analysis for risk assessment of breast cancer. The technique provides objective risk assessment for the presence of a malignant tumour based on automated parameters derived from a clinically known training set.
Following institutional review board approval, we recruited 434 women for this prospective multicentre trial, including 256 healthy woman undergoing routine screening mammography with BI-RADS-1 results and 178 women with newly diagnosed breast cancer. This was a two-phase study: an initial training and calibration phase, followed by a two-armed blinded evaluation phase (52 healthy and 66 with breast cancer). 3DIRI data sets were acquired using a non-contact, no radiation system.
The sensitivity and specificity of functional infrared imaging in providing the correct risk for the presence of breast cancer were 90.9 % and 72.5 %, respectively. The area under the ROC curve was 86 %. Forty-two of the 60 (70 %) cancers in women correctly classified by the system as suspicious were smaller than 20 mm in size.
The preliminary blinded results of this novel technology show sufficient performance of functional infrared imaging in providing risk assessment for breast cancer to warrant further clinical studies.
• 3D functional infrared imaging (3DIRI) provides new metabolic signatures from breast lesions. • 3DIRI offers high sensitivity for risk assessment of breast cancer. • It also has reasonable specificity. • This initial experience warrants further evaluation in larger clinical trials. Source: http://www.ncbi.nlm.nih.gov/pubmed/?term=23223805